Religion and Video Games almost never mix. At least not in the way you might think. Sure there are cult references all over the place, but there are few and far between games that rely heavily on purely religious stories and tones to make the entertainment package worth while.
What does that even mean?
I mean that there are few games based on religion. The few games that I have played were terrible and I do mean terrible!
When it comes to controversial subjects, nothing leads to shouting matches quite like introducing religion into the mix. While the video game industry is usually willing to court controversy when the potential payoff is worth it, concepts of spirituality and faith have generally been avoided by both developers and publishers.
In fact, religion seems to be such a taboo subject to include in video games that the only type of faith that really appears in titles here in the US is Christianity. Even then, the subject is often poorly addressed in games that are themselves poorly made. But why is it that religious content is so sparse in the realm of video games? The reasons are largely based on contention between religious and industry leaders, as well as the fact that you'll rarely find a topic as personal as faith.
You can read more about religion and video games via arstechnica.com
The best thing I could do to illustrate my point even further is this video review of "religious" games via The Angry Video Game nerd. Oh and it's NSFW!